Extracellular Matrix: The Secret Sauce of 3D Cell Culture

Extracellular Matrix: The Secret Sauce of 3D Cell Culture

With 3D cell culture making strong inroads into preclinical studies and basic research, the focus of vendors and investigators alike has turned from discovery to optimization. What kinds of organoids, spheroids, or nondescript 3D cultures work best? What should their cellular composition be?..

When designing 3D cultures—organoids, spheroids, organ-chips, etc.—scientists tend to look for an off-the-shelf answer, much as they do with cell culture media. But in nature ECM composition varies significantly throughout organisms, from tissue to tissue and organ to organ. “Its structure and biochemical composition are highly specific to organs and disease states,” says Tanya Yankelevich, Director of Product Management, Xylyx Bio. Read more >>

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